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Self-emulsifying Agent Solubilizer SL-11

Solubilizer SL-11 is clear liquid with superior solvent properties for many kinds of hydrophobic drugs to prepare nano emulsion. Particle size of nano emulsion is below 50 nm. Solubilizer SL-11 is highly suitable for SEDDS (Self Emulsifying Drug Delivery System) agent and can help intestinal absorption higher. Nano emulsion and SEDDS agent containing hydrophobic drugs can be easily prepared by simple protocol below.



Cutting-Edge Technology for Self-emulsifying Agents
(Particle size: < 50nm)
  • Easy preparation
  • Applicable to various kinds of hydrophobic drugs
  • Applicable to soft capsules for oral use
  • Most suitable for SEDDS agent
  • Improvement of intestinal absorption following oral administration
  • Comply with Toll development for formulations
  • Comply with bulk supply requests
Method   ［ Method I ］

(1) Dissolve drug in a suitable solvent, such as ethanol, etc.

(2) Add the drug solution prepared in (1) to Solubilizer SL-11, thoroughly mix to completely dissolve the contents.

(3) The drug/SL-11 solution with solvent is made.

(4) Evaporate the solvent at 50℃ for about 1 hour to remove the solvent, or remove the solvent under a nitrogen stream.

(5) Concentrated solution of SL-11 and the drug is made.

(6) Soft capsules can be prepared by using the concentrated solution in (5) .


［ Method II ］

(2) Depending on the drug, it can be dissolved directly in SL-11. If required, warm the solution to about 50℃ to dissolve completely.

(5) The concentrated solution of SL-11 and the drug is made.

(6) Soft capsules can be prepared by using the concentrated solution in (5) .

[Specification]
Content : mixture of pharmaceutical excipients
Volume : 50g , 100g , 1kg
Container : glass bottle
Storage : Storage under room temperature. Keep container closed.

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